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KMID : 0614620010370040287
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Korean Journal of Gastroenterology
2001 Volume.37 No. 4 p.287 ~ p.290
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A Case of Lichen Planus during Interferon Treatment for Chronic Hepatitis C
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김성목/Sung Mok Kim
채두근/박경동/하정수/박은택/이연재/이상혁/설상영/정정명/Doo Keun Chae/Kyung Dong Park/Jung Soo Ha/Eun Taek Park/Youn Jae Lee/Sang Hyuk Lee/Sang Young Seol/Jung Myung Chung
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Abstract
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Lichen planus(LP) is a chronic inflammatory disease of unknown cause with variable clinical presentations on skin and mucosa. LP is frequently observed in patient with hepatitis C virus infection and can occur or exacerbate during interferon
treatment.
We report a case of LP which developed and was aggravated during interferon treatment on chronic hepatitis C. The patient was a 44-year-old man who was diagnosed as chronic hepatitis C on liver biopsy. We started interferon alpha treatment in a
dose of
3 million units subcutaneously 3 times weekly. Five months later of interferon treatment, erythematous erosive skin lesion on lower lip was found and it was aggravated progressively. Skin biopsy showed LP. The condition of the patient was
improved
with
local treatment after discontinuation of interferon injection
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